Symbol
Name
ID

Dclre1c
DNA cross-link repair 1C
MGI:2441769

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Increased circulating IgE level

Decreased circulating IgG level

Decreased circulating antibody level

Panhypogammaglobulinemia

Purpura

Anemia

Hemolytic anemia

Eosinophilia

B lymphocytopenia

Severe B lymphocytopenia

Decreased proportion of CD3-positive T cells

Abnormally low T cell receptor excision circle level

Lymphopenia

Thrombocytopenia

Autoimmune thrombocytopenia

Lymphoma

Splenomegaly

Disease(s) Associated with DCLRE1C

common variable immunodeficiency

Omenn syndrome

severe combined immunodeficiency with sensitivity to ionizing radiation

Mouse Phenotypes

decreased B cell proliferation

decreased T cell proliferation

absent thymus cortex

decreased thymus weight

decreased thymocyte number

decreased DN1 thymic pro-T cell number

decreased DN4 thymocyte number

abnormal B cell differentiation

abnormal class switch recombination

absent immature B cells

abnormal immunoglobulin heavy chain V(D)J recombination

increased pro-B cell number

arrested B cell differentiation

abnormal T cell receptor V(D)J recombination

abnormal T cell receptor beta chain V(D)J recombination

decreased double-positive T cell number

arrested T cell differentiation

increased neutrophil cell number

decreased mature B cell number

decreased B-1 B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

decreased NK T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

abnormal mononuclear cell morphology

small spleen

spleen hypoplasia

abnormal spleen B cell follicle morphology

decreased splenocyte number

abnormal leukocyte physiology

decreased IgM level

Availability

Mouse Genotype

Dclre1c^m1Brck/Dclre1c^m1Brck

Dclre1c^m1Btlr/Dclre1c^m1Btlr

Dclre1c^M2Btlr/Dclre1c^M2Btlr

Dclre1c^m3Btlr/Dclre1c^m3Btlr

Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa

Dclre1c^tm1.1Jpdv/Dclre1c^tm1.1Jpdv

Dclre1c^tm1Fwa/Dclre1c^tm1Fwa

Dclre1c^tm1Jsek/Dclre1c^tm1Jsek

Dclre1c^tm2.2Jpdv/Dclre1c^tm2.2Jpdv

Dclre1c^tm2Mcow/Dclre1c^tm2Mcow

Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv
Tg(Cr2-cre)3Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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